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Abstract

Antimicrobial Resistance (AMR) is a growing concern in the medical field. Over-prescription of antibiotics as well as bacterial mutations have caused some once lifesaving drugs to become ineffective against bacteria. However, the problem of AMR might be addressed using Machine Learning (ML) thanks to increased availability of genomic data and large computing resources. The Pathosystems Resource Integration Center (PATRIC) has genomic data of various bacterial genera with sample isolates that are either resistant or susceptible to certain antibiotics. Past research has used this database to use ML algorithms to model AMR with successful results, including accuracies over 80%. To better aid future biologists and healthcare workers who may need a predictive model without the benefit of thousands of bacteria samples, this paper explores quantifying the empirical quality of some machine learning models—that is, quantifying how well a model will perform without prior knowledge of how the model performed on a training dataset. WeightWatcher is a Python package that offers various algorithms to measure model quality. This research uses the empirical quality metrics that WeightWatcher introduces for Deep Neural Network (DNN) models to evaluate AMR models, even on datasets based on small sample sizes of bacterial strains. The use of ML in AMR and pharmacogenetic research can help lead to increased efficacy of antibiotic treatments by predicting whether a strain of bacteria will be resistant or susceptible to an antibiotic.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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