Dr. Peng Tao
Nitric oxide (NO) is a critical cell-signaling messenger in the immune, cardiovascular, and nervous systems. It is linked to several diseases, and due to its high reactivity, and toxicity as a free radical, NO possesses a controversial effect on cell viability. The S-nitrosylation of protein thiol groups is a key mechanism in NO redox signal transduction, and lends a mechanistic basis for NO as a cell regulator. Numerous experiments have shown that the rate-limiting step of S-nitrosylation is NO autoxidation, independent of thiol concentration. Due to the transient nature, and structural variety of reactive nitrogen species, very little is known about the mechanisms of either NO autoxidation or S-nitrosylation.
Engaged Learning 2014
Chemistry | Other Chemistry | Physical Sciences and Mathematics
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Abusad, Yazen, "Computational Study of the Nitric Oxide Autoxidation Mechanism Using Quantum Chemistry Methods" (2014). Engaged Learning Collection. 33.