Subject Area

Biostatistics

Abstract

The stepped wedge (SW) cluster randomized design has been increasingly employed by pragmatic trials in health services research. In this study, based on the GEE approach, I present a closed-form sample size that is applicable to both closed-cohort and cross-sectional SW trials with outcomes from the exponential family. On the other hand, I proposed a Bayesian adaptive design for cross-sectional SW cluster randomized trials. It is more adaptable than traditional designs because it allows early termination of the trial when interim data indicate that the intervention is sufficient efficacious or inefficacious. A decision to terminate or continue the trial will be made on the basis of the predictive probability. This probability is the chance of getting a conclusive result at the end of the study based on the interim data collected so far.

Degree Date

Fall 2019

Document Type

Dissertation

Degree Name

Ph.D.

Department

Statistical Science

Advisor

Song Zhang

Second Advisor

Chul Ahn

Number of Pages

71

Format

.pdf

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Included in

Biostatistics Commons

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